The enhancemeny of anti-tumor effects, immuno-activity and radiation protection after injection of EF 2001

Abstract

EF2001 was made from Enterococcus Faecalis, and it has radiation protection effects by protection of the intestinal mucosa in the absorption function of the carcinogenesis materials. We used animals were C3H mice bearing SCC-7 tumor. The mice irradiated with X-ray hole body after intraperitoneal infection of EF2001. Body weight was smaller in mice injection EF2001, as control group after 3 days. No apparent difference was found between two groups injected EF2001.There was tendency to prolong the survival in the groups injected EF2001. In the intestine, mucosal damage was protected in both EF2001 12 mg and EF2001 24 mg groups.The tendency that damage was few included a one of EF2001 24 mg group in the small intestine. Activities of NK cells were enhanced 1.46 and 1.94 times in EF2001 24 mg groups respectively.EF2001 doesn't absorption of nutrient matter, and there is function that absorption does Trp P-1 and Trp P-2 which is carcinogenesis. The results of this study confirmed, EF2001 has effect of radiation protection. EF2001 can absorption of carcinogenesis materials selectively.