Host: The Japan Radiation Research Society
Co-host: Asian Association for Radiation Research
Immune function degradation is noted it for a side effect of radiotherapy. In this study, we reviewed the presence about anticancer activity by lignin of an active ingredient origin of a pinecone, antioxidation, adjuvanticity. As for the leukocytes, the lymphocytes change, 2Gy irradiated lignin after administration in 360mg/kg abdominal cavity per ICR mice body weight for three weeks. Even antioxidation activity measured SOD activity in serum equally. About immune globulin total IgG, the measurement of quantity of IgM, we used C3H laboratory mouse and measured total IgG and quantity of IgM. About analysis of T lymphocyte subset, fluorescence staining of flow cytometry assumed lymphocyte of C57BL mouse it and analyzed CD4 and CD8. About a radioprotective effect of lignin for a blood cell, there were leukocyte count and lymphocyte counts decrease depression effect. In addition, decrease of quantity was accepted about an antioxidation effect and IgG, IgM antibody formation. In addition, there were CD4 by lignin administration and increase of a CD8 positive rate. It was the radical scavenging effect that resulted from radiation exposure and controlled decrease of leukocytes, and lignin prevented degradation of immunology force and controlled immunology force degradation with radiation exposure by increase effect such as activity and T cell activity of a macrophage or INF-Γ, and what radiation protection did was found.
