The Japan Radiation Research Society Annual Meeting Abstracts
The 50th Annual Meeting of The Japan Radiation Research Society
Session ID : EP-150
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Modifing Factors of Radiation Effects
Anticancer and radiation protection effect for each kind agaricus
*Takenori YAMASHITAMario KIMURAMinoru HIRANOYuka ITOKAWAYeunhwa GU
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Abstract
We reviewed an anticancer effect and radiation protection of various agaricus. We reviewed antioxidation, SOD activity, immunisation activity to review mechanism. We transplanted an SCC -7 cancer cell using C3H and performed 6Gy/ three times division local irradiation. We administered it every day, and the medication method of various agaricus measured it. We used an SOD activity detection kit as an antioxidation experiment and tested it. We used it and analyzed CD4/CD8 by flow cytometry in T lymphocyte of C57BL mouse.In addition, we examined IL2, IL12. With control group, protection of Japanese product agaricus and T lymphocyte of a Brazilian product agaricus treated group was found in comparison with irradiation group. In addition, a rise of humoral immunity is thought about from IL2, activity of IL12. We compared it with control group, and, about antioxidation action, activity of SOD was recognized glucan treated group. In addition, tumor growth of various agaricus treated groups was inhibited. Various agaricus lowers activity of dehydrase, and it is thought that we disturbed metabolism of tumor cells while, on the other hand, putting up activity of a catalase. It is thought that we restrain fissiparity of a cancer cell by immunisation activity by glucan when various agaricus causes cell protein and a fall of a division index.
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© 2007 The Japan Radiation Research Society
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