The Japan Radiation Research Society Annual Meeting Abstracts
The 50th Annual Meeting of The Japan Radiation Research Society
Session ID : W3R-336
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Host: The Japan Radiation Research Society

Current Topics in DNA Double-strand Break Repair
Establishment of experimental system to analyze epigenetical effect of DNA double strand break
*Norio UEMATSU, Ohtsura NIWA, Akira FUJIMORI
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Keywords: DSB, epigenetic, chromatin
CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

DNA double strand break (DSB) is one of major DNA damage caused by irradiation. The impact of this damage including the biological responses such as its repair has been extensively described. Since formed as chromatin in vivo, histones, major component of chromatin, has to be released to make naked DNA before the repair of DSB. It has been also known that histones like H3 or H4 could be modified to control chromatin status. To understand if the chromatin status could be maintained through the DSB repair, we are establishing an system to analyze the modification of histones around DSB site. We will present the current data.

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© 2007 The Japan Radiation Research Society
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