Disease biology of radiation-induced disorders from the viewpoint of nuclear organization

Abstract

The nucleus is a place where genetic information is maintained by correct replication and segregation of chromosomal DNA and expressed by transcriptional machinery. To exert such fundamental reactions that are required to maintain biological functions efficiently, inner spaces in the nucleus are functionally separated to a high degree without membrane, displaying dynamic organization. To gain further insight into the mechanisms of systemic disorders resulting from radiation exposure, in addition to each fundamental cellular function, dynamic organization of the nucleus should be explored. In this workshop, we will discuss novel findings of nuclear organization, mainly repair pathways that respond to DNA damage, in association with diseases and try to understand the mechanisms underlying radiation-induced disorders, which are hardly understood by conventional researches.