Abstract
It has been shown that isonicotinic hydrazide (INAH) induces the so-called running fit and this seizure is not suppressed by vitamin B_6. On the contrary, the administration of vitamin B_6 shortens the time interval of onset of the seizure. The action of INAH on the enzyme system involved in the running fit was studied. Results clarifying the effect of INAH on the brain enzyme system and the intensification of the seizure by vitamin B_6 were obtained.
