Analysis of Cardiovascular Pathophysiologies Due to Abnormal Regulation of Nuclear Functions

Abstract

Epigenetic regulation has been recently shown to play a central role in cardiovascular pathologies. Chromatin remodeling factors including histone modifiers and enzymes have been shown to regulate developmental processes to pathologies such as cardiac hypertrophy and even aging at the molecular, cellular and animal levels. This has brought upon a paradigm shift from the classical thinking weighed on signaling pathways to that of emphasis on nuclear regulation and processes. Research in this field is still in early stages, however.
Data from our lab showing involvement of epigenetic regulators in cardiovascular pathologies will be discussed. Notably, involvement of chromatin remodeling molecules and DNA damage/repair molecules in cardiovascular pathologies at both the cellular and animal levels will be discussed.