Abstract
Radiobiological effect is a complex multistep-event containing the physical, chemical and biological sub-steps. Among the sub-steps, DNA damaging (between chemical and biological steps) is the most important one leading the final consequences such as cell death and transformation, because it is the initial step with bio-molecular changes directly ad initium. Thus, to study DNA damage has always occupied an important place in radiation biology. Recently, DNA damage in radiation biology is thought to be stating of obvious matter, and reports for DNA damage are decreasing in the late meetings. However, there have been the most studies for only simple structural damage such as DNA double strand break and oxidative base lesions. We have less knowledge about more complex structural damage like clustered DNA damage and cross-link damage, and about DNA damage induced by heavy ion beams. Additionally, we often tend to conventional analyzing method without necessary deliberation. In this workshop, we provide three progress reports about such important themes for undefined problems including clustered DNA damage and cross-link damage, and also present an issue about analyzing method for radiation DNA damage. Finally, we offer the special featured histrical review for this theme by Dr. Osamu Yamamoto, a great emeritus professor for radiation DNA damage.
