Abstract
Each cell in a population is inhomogeneously irradiated with X- or γ-rays at low dose or low dose-rate, according to Poisson distribution. Thirty seven % of cells, which are not irradiated with X- or γ-rays at all, are contained within the cell population, however, it is much difficult that these unirradiated cells are distinguished. Om the other hand, since it is easy to analyze cellular response to radiation with distinguishing irradiated cells from unirradiated ones with microbeams of X-rays or heavy particles, many reports regarding the contribution of bystander response to classical cellular responses to radiation has been published now. In this Workshop, we must clarify the problems to establish a new global ‘concept of dose’ to compare easily certain phenomena after irradiation by broad beams with certain phenomena after irradiation by microbeams, and we must discuss strategy to solve these problems.
We would present several topics regarding bystander and adaptive responses induced after irradiation of heavy particles with different LET, in order to clarify the problems to establish a new global ‘concept of dose’ and to discuss strategy to solve these problems.
