ラット熱傷モデルに対する大気圧低温プラズマ照射の有効性の検討

抄録

　Current skin wound treatments have side effects such as skin atrophy and drug allergies, and there is a need for less invasive treatment methods. Medical applications of atmospheric low-temperature plasma (ALTP) have been promoted in recent years. Skin wound treatment is one of these applications. In this study, we focused on burn wounds, which are one of skin wounds and can form scars and investigated the effect of ALTP on burn wounds: ALTP treatment shortened the healing time of the burn site, and gene expression analysis by RT-qPCR showed that the expression levels of VEGF-a and HIF1a, which are related to angiogenesis, increased. These results suggest that ALTP accelerates healing by activating the HIF1a/VEGF-a pathway and promoting angiogenesis in wound tissue.