Animal Test and Clinical Application of Hollow Fiber Oxygenator for 100 cases of Open Heart Surgery

Abstract

The polypropylene hollow fiber oxygenator (H. F. O.) was tested in animal experiments and applied to 100 cases in open heart surgery.
8 dogs were used as test animals for H. F. O. using veno-arterial bypass method. The 1.0 M² H. F. O. was perfused 5 hrs continuously with an average of 1.0 l/min of venous blood at 37°C and pure oxygen at a rate of 1.0 l/min. Average O₂ transfer rate was 43±3ml/min/M² and CO₂ transfer rate, 43±2ml/min/M² when Hb was 10.5g/dl. Free hemoglobin after 5 hr perfusion was 38.0±16.6 mg/dl. 100 cases including 77 congenital and 23 acquired heart diseases were operated using 1.8 or 3.3 M² H. F. O.. Perfusion time was 74±66 min and free hemoglobin was 41.6±34.4mg/dl at the end of CPB. Average blood perfusion rate was 2500± 1000ml/min and pure oxygen gas to blood flow ratio was 0.53±0.21. PaO₂ was 467±62 mmHg and PaCO₂ 29±5mmHg when average Ht was 24±5%.
This H. F. O. was observed to have excellent capability of oxygen and carbon dioxide gas transfer with small amount of hemolysis in 100 patients undergoing open heart surgery