人工臓器
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
低分子たんぱくの透過性からみた血液濾過用フィルターの性能評価
岩本 均馬場 操松井 則明吉山 直樹中川 成之輔武内 重五郎北岡 建樹
著者情報
ジャーナル フリー

1981 年 10 巻 1 号 p. 233-236

詳細
抄録
Performance of six filters was evaluated by measuring sieving coefficient (SC) and plasma concentration of low-molecular-weight proteins (LMWP); β2-microglobulin (β2-mg, MW 11, 800), lysozyme (MW 14, 000), myoglobin (MW 17, 500), retinol-binding protein (RBP, MW 21, 000) and α1-microglobulin (MW 33, 000), Permeability of LMWP was much lower in filter membranes than that of glomerular basement membrane, For example, SC of lysozyme and myoglobin in most permeable filter, Hemofresh was only 0.32 and 0.17 while they are 0.80 and 0.75 in natural glomerulus. Plasma leveles of β2-mg, lysozyme and myoglobin were reduced after one hemofiltration procedure by Hemofresh.
But elevated plasma levels of LMWP were not reduced even by the long-term maintenance in hemofiltrationo In conclusion, more permeable filter for LMWP is required to make hemofiltration as a device of artificial kidney more akin to natural kidney.
著者関連情報
© 一般社団法人 日本人工臓器学会
前の記事 次の記事
feedback
Top