人工臓器
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
無ヘパリン透析用抗凝固薬としてのプロスタグランジンE1およびD2の有用性について
松井 則明小沢 潔中村 義弘秋葉 隆吉山 直樹中川 成之輔武内 重五郎
著者情報
ジャーナル フリー

1981 年 10 巻 1 号 p. 245-248

詳細
抄録
As heparin cannot inhibit platelet function, there is a possible situation in hemodialysis in which another supplementary platelet inhibitor is required for successful anticoagulation. In this regard, prostaglandin (PG) E1 and D2 were evaluated as antiplatelet agents during hemodialysis.
Inhibitory effect of PGD2 on platelet aggregability in vitro was more potent than PGE1 by about 3 Times. Judging from adverse effects, PGD2 can be administered twice as much as PGE1 during hemodialysis. Consequently, more potent inhibitory activity on platelet can be expected clinically in PGD2 than PGE1 by 5 times. PGE1 can be used as a supportive agent fcr heparin. PGD2 can be expected as an agent for regional anticoagulation.
著者関連情報
© 一般社団法人 日本人工臓器学会
前の記事 次の記事
feedback
Top