We developed ion-exchangeable membrane composed of semi-permeable membrane, ion exchange resin and diffusion barrier membrane. In in vitro studies, ion-exchangeable membrane had ion exchange capacity for 4mEq of cation and 3.3mEq of anion per each gram of ion exchange resin. In in vivo experiments with acute renal failure dogs, electrolyte and acid-base disturbances in uremia were improved with blood perfusion to ion-exchangeable membrane device.
These results indicate that ionexchangeable membrane can be applied for the compact type of artificial kidney.
