抄録
A new ammonia adsorption system was developed using silicate complex (TTY 500) and evaluated by means of in vitro and in vivo study. In vitro study evidenced that ammonia adsorption rate was 72.2%. In vivo study showed that serum ammonia in hepatic failure dogs decreased during the hepatic assist.
Direct hemoperfusion with charcoal coated by polyurethane (AAC) was carried out for the hepatic failure dogs. Satisfactory blood biocompatibility was obtained. The AAC-DHP group (4 dogs) at this prognosis was compared to the control group (17 dogs). During DHP there was significant decrease in serum tryptophan but no significant difference between both groups in survival time.
