抄録
Two kinds of newly designed dialdehyde starch (DAS; oxystarch) whose surface aldehydes were treated with either albumin or gelatin, were evaluated about their adsorptive capacity for urea and guanidino compounds in vitro, and their effects on serum concentration of nitrogen wastes in vivo. In in vitro studies, they adsorbed two times of urea compared with non-treated DAS, but showed no significant differences in adsorption of guanidino compounds. When administered 20g/day of the treated DAS orally for ten days to a stable anuric chronic renal failure patient on regular hemofiltration, BUN was reduced about 20% from control value without any adverse reactions. Serum concentration of creatinine and uric acid remained to be unchanged.
These results indicate that newly designed DAS is useful too treat uremia, especially as a supplemental therapy for compact artificial kidney systems.
