Abstract

Removability of mitomycin C (MMC) by charcoal was studied pharmacokinetically. Mongrel dogs weighing 10-17kg were anesthetized by pentobarbital and femoral vessels were canulated with usual dialysis needles. Immediately after 1mg/kg of MMC was systemically administered, direct hemoperfusion over charcoal (DHP) was initiated with blood flow 100ml/min for 180min.
Two-compartment open model was applied to this pharmacokinetical analysis. First component, distribution phase, were estimated to be C(T)=1.675e^-0.064t in DHP group and C(T)=5.22e^-0.056t in control, distribution volume V₁ were 0.660l/kg in DHP group and 0.230l/kg in control. Second component, elimination phase, had almost same excretion rate in two groups.
A rapid excretion rate and a large distribution volume of MMC in early phase were observed in DHP group associated with reduction in its untoward effects.