Molecular Design of Microdomain Surfaces Having the Ability to Prevent Platelet Activation

Abstract

We have proposed that the microdomain structure of the polymer surface, constructed by hydrophilic and hydrophobic chains, is most important parameter to design good antithrombogenic polymers. In this paper, the morphological and dimentional effects of microdomain structures on the mode of interaction between amphiphilic block copolymers and platelets were studied by the microsphere column method. It was found that the microdomain structures showed the ability to prevent deformation and release reaction of adhered platelets.