Control of B and T Lymphocyte Adhesion by Polystyrene/Polyamine Comb-type Copolymer having Microphase Separated Structures

Abstract

Adhesion behavior of rat mesenteric lymphnode lymphocyte on various polymer surfaces was kinetically studied by using column method. Polystyrene/polyamine comb-type copolymer (SA copolymer) surfaces having microphase separated structure was found to exhibit a unique adhesion behavior toward lymphnode lymphocytes: (i) the adhesion of lymphocyte was segnificantly suppressed on the surfaces of SA copolymer, and (ii) the surfaces of SA copolymer were able to differentiate B lymphocyte from T lymphocyte in terms of adhesivity.