Abstract
Φ5mm Gore-Tex graft was implanted to the femoral artery of mongrel dog and Prostacyclin (20ng/kg/m) was infused. The platelet aggregation by ADP 30μg was inhibited and the blood flow was increased.
Prostacyclin decreased the adhesion of platelets and the thrombus formation of the graft, therefore prevented the early occlusion. Late graft failure by intimal hyperplasia is also prevented because Prostacyclin reduses the platelet factor that stimulates the smooth muscle cells to miglate and proliferate.
