Abstract
Collagen is a major component of the extracellular matrix in living tissues and can influence the adhesion, morphology and migration of cells and in some cases, differentiation. On the other hand, since mucopolysaccharides (glycosaminoglycans) possess multiple anionic charges and have strong affinity for water, the resulting water layer may inhibit adhesion of platelets to the surfaces. For this reason, a hybrid matrix consisting of collagen and mucopolysaccharide may be a blood- and tissue-compatible material. Our results indicate that collagen/hyaluronic acid matrix markedly inhibits platelet adhesion, furthermore, the proliferation of fibroblasts on collagen/hyaluronic acid matrix as well as on collagen matrix is well.
