Abstract
Hollow fiber artificial kidney (HFAK) which has an ability for high protein permeability, using polysulfon membrane was evaluated in kidney center, kitasato university hospital. In order to render dialysis therapy mere comfortable and efficient, studies were done not only on permeability of membranes for various solutes and fluid put also on biocompatibility of membranes. The performance and characteristics of the membrane are as follows: Type, A: thickness: 40 microns, tatal surface area: 1.48m2, ultrafiltration: 29.4ml/h/mm of Hg, blood volnme: 100ml, clearance, measured in vivo: urea 167ml/mn, creatinine 147ml/mn, β2MG 46ml/mn, . Type, B: thickness: 39 microns, total surface ares: 1.25m2, ultrafiltration: 22.5ml/h/mm of Hg, blood volume: 100ml, clearance, measured in vivo: urea 151ml/mn, creatinine 127ml/mn, β2MG 32ml/mn. Dialysance and UFR is stable throughout dialysia session. The phenomenon of leukopenia and complement activation during hemodialysis session were much better than cellulosic membrane. we also observed the behaviour of albumin, transferrin and immunoglobulin. Data obtained thus suggest that in some patients evacuation of large molecular protein in dialysis was proved to be safe and effective for relief of clinical symptoms, i. e, itching, in long term dialysis. Finally, we want to stress that this new HFAK has improved action on blood compatibility and biocompatibility.
