Abstract
MD805, a synthetic thrombin inhibitor was evaluated as an anticoagulant for hemodialysis in comparison with heparin. Hemodialysis with MD805 was done for 12 weeks. Hollow fiber thrombosis was observed more frequently in hemodialysis with MD805 than with heparin. Although remarkable increase of free fatty acid and decrease of triglyceride was observed in hemodialysis with heparin, both was not changed in hemodialysis with MD805. Reduction of PaO2 during hemodialysis with heparin did not observed in hemodialysis with MD805. Antithrombin III increased slightly but significantly in hemodialysis with MD805. In conclusion, MD805 is a useful anticoagulant for hemodialysis because of some advantages over heparin.
