Right ventricular performance on afterload reduction or pressure overload to left ventricule

Abstract

The purpose of this study was to characterize the Right ventricular (RV) performance while varying Left ventriculer (LV) afterload. 10 dogs (25±3.0kg) were subjected to roller pump to esterblish a LV afterload reduction (-30mmHg) by wlchdrawing blood from descending aorta, and a LV pressure overload (+60mmHg) was produced by placing snare on the descending aorta. RV pressure, it's first derivative (dp/dt) and contractile force (Strain gauge, SG) LAP, Aop, LVdp/dt, LVSG, were recorded. All measurements were compared before and after the ligation of the septal perforator. Our experimental results suggested that the detrimental effect on RV function during afterload reduction to LV (IABP) for septal infarction resulted from the influence of ventricular septum.