Evaluation of non coated XAD-4 hemoperfusion in dog with acute hepatic ischemia

Abstract

Non coated XAD-4 hemoperfusion system was evaluated in dog with acute hepatic ischemia. Experimental group were as follows; 1. Control: ischemic liver without DHP (5 dogs) 2. DHP (3) 3. DHP with blood exchange (2) The highest survival rate was found in group 3. In the control group, all animals except one died within 38 hours after surgery. Blood coagulation and lysis system were examined. During DHP, the too Fbg, PT, HPT, and Antithrombin III were decreased 50 to 70% and FDP increased markedly in group 2 and 3. DHP combined with blood exchange might be useful, but the disturbance of blood coagulation and lysis system was main problem for further clinical use.