-
[in Japanese]
1984 Volume 13 Issue 2 Pages
595
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
K SOEDA, M ODAKA, H HIRASAWA, H KOBAYASHI, Y TABATA, M OHKAWA, S ODA, ...
1984 Volume 13 Issue 2 Pages
597-600
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We analyzed the rehabilitation state among 234 patients having been treated with HD more than one year. During induction, twenty-two percent of them lost their jobs. Overall rehabilitation rate was 84%. Improvement in methods of rehabilitation would be shortened duration of induction and wide application of night dialysis. Furthermore, short time dialysis with DHP and CAPD would be effective. However, the increase in aged and long-term survival patients remains as a problem to be discussed for the future.
View full abstract
-
A. YAMASHITA, H. HIDAI
1984 Volume 13 Issue 2 Pages
601-604
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Economical therapy is needed for patients who are being treated with haeriedialysis, because the number of the patients is increasing more and mere. Our setting up method of therapeutic conditions makes it possible to save spending four thousand million yen, considering only for dialysate in a year. For home haemodialysis, shorttime and frequent therapy is one of the best technique from mass transport point of view, if the problem of reusing dialyzers is cane to a decision.
View full abstract
-
N. SUZUKI, K. MAEDA, T. YAMAZAKI, H. KAWAHARA, I. AMANO, K. MOROZUMI, ...
1984 Volume 13 Issue 2 Pages
605-607
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The retrospective study of the maintenance hemodialysis in Aichi shows both a high survival rate and a good full rehabilitation of the chronic dialysis patients. In future, a group of dialysis patients who can neither rehabilitate nor be discharged will increase, so the satellite center for the dialysis treatment should also be available for these patients and the center bospital should serve the severe complication of the chronic dialysis patients. It is a socio-economic benefit to systematize the dialysis center in a region and to promote the maintenance dialysis as a part of the treatments of the renal diseasa.
View full abstract
-
K. ITO, M. KONO, F. NARUMI, H. KAWAGUCHI, N. ITAMI
1984 Volume 13 Issue 2 Pages
608-610
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The incidence of chronic renal failure (CRF) of children in our country had been increasing annually until 1980, however, afterwhich, it became to decrease to be fixed at around the incidence of 80-100/year. It seemed that such decrement and fixation of the incidence of CRF mainly depend upon the prevalence of mass urinary examination at school and the increment of children with CRF underwent renal transplantation.
According to the paper test performed on the patients undergoing hemodialysis treatment in our institute, it was confirmed that almost all patients can attend school and afford the usual curriculum, moreover, they wanted to be independent in thier future.
View full abstract
-
-role of dialysis physician-
Tadasu SAKAI
1984 Volume 13 Issue 2 Pages
611-612
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Truely great strides have been taken in the development of the dialysis therapy, which become accepted measure for the treatment of chronic renal failure. However, though progress has been made, there remain a great deal of problems, associated with physical, psychological, social, geographycal, philosophycal and economical factors. Concerning on the final ideal system of the dialysis therapy, it is still long way to go until we achieve to solve those remaining factors of the treatment itself. In this report, I would like to direct your attention to the following five problems: (1) What is the best modality for the blood purification? (2) How to solve the problems of rehabilitation in patients on chronic dialysis program? (3) How come socio-economical status concerning on dialysis therapy in future? (4) What shall we do for solving many physical factors as dialys-is physician? (5) How to behave as team leader in ideal system of the dialysis therapy?
View full abstract
-
[in Japanese], [in Japanese]
1984 Volume 13 Issue 2 Pages
613
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
H. KAWANISHI, M. NISHIKI, H. EZAKI, S. YAMANE, T. TSUCHIYA, M. SUGIYAM ...
1984 Volume 13 Issue 2 Pages
614-617
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
UPC, which is 15cm width, 35m length and 200μm thick, was rolled and filled in a column of PP. During DHPs for jaundiced and hepatic failure dogs, removal amounts of 70% in bilirubin and good consciousness recovery were obtained. Our UPC can successfully remove protein-bound and middle molecular substances, and suggests that DHP using the UPC system may be effective for the treatment of hepatic failure.
View full abstract
-
T. TSUBURAYA, M. MATSUSHITA, A. KAKITA, T. TAKAHASHI, T. KUSHIDA, M. T ...
1984 Volume 13 Issue 2 Pages
618-621
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Non coated XAD-4 hemoperfusion system was evaluated in dog with acute hepatic ischemia. Experimental group were as follows; 1. Control: ischemic liver without DHP (5 dogs) 2. DHP (3) 3. DHP with blood exchange (2) The highest survival rate was found in group 3. In the control group, all animals except one died within 38 hours after surgery. Blood coagulation and lysis system were examined. During DHP, the too Fbg, PT, HPT, and Antithrombin III were decreased 50 to 70% and FDP increased markedly in group 2 and 3. DHP combined with blood exchange might be useful, but the disturbance of blood coagulation and lysis system was main problem for further clinical use.
View full abstract
-
H. HIRASAWA, M. ODAKA, H. KOBAYASHI, Y. TABATA, H. OHKAWA, K. SOEDA, S ...
1984 Volume 13 Issue 2 Pages
622-625
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
During 1975 to 1979, we treated 21 AHF patients in grade III or IV coma with direct hemoperfusion and/or plasma exchange. Amont these 21 patients, only 3 survived. In 1979, we decided to initiate those treatments for AHF when the patients were in the early stage of AHF. Six patients in grade II or III coma were treated with this policy, using arterial ketone body ratio as an indicator for accurate and early diagnosis for AHF, and 4 survived. Therefore, we concluded that the early initiation of the artificial liver support was effective.
View full abstract
-
S. KASAI, H. ASAKAWA, T. YAMAMOMOT, M. SAWA, K. KONDHO, S. SEKIGUCHI, ...
1984 Volume 13 Issue 2 Pages
626-629
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The technique of cryopreservation of isolated hepatocytes obtained from beagle by collagenase digestive method were developed to use the metabolic support device. After thawing, the viability and the metabolic functions decreased about 70% and 50% respectively. The activities of the device were evaluated by in-vitro and in-vivo animal experiments. Ammonia concentration decreased remarkably and the other chemical parameters maintained within normal range.
View full abstract
-
[in Japanese]
1984 Volume 13 Issue 2 Pages
630
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
E. KINUGASA, K. TAMURA, T. SEKIGUCHI, F. NAKAYAMA, K. TAKAHASHI, T. AK ...
1984 Volume 13 Issue 2 Pages
631-634
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
This study was performed to clarify the deposition of various plasma proteins to dialysis membrane during hemodialysis with the lmmunofluorescence (IF) technique and to estimate the influence of membrane materials and anticoagulants on that. Evaluated materials were Cuprophan (CP), saponified cellulose (SC), cellulose acetate (CA) and PMNIA membrane. Four types of anticoagulants, namely, heparin, MD-805 (anti-thrombin agent), FUT-175 (multi-enzyme inhibitor), and OP-41483 (prostaoyclin derivative) were also estimated. After the preparation of cryosections of hollow fibers immediately after the hemodialysis, the deposition of various proteins such as C
1q, C
3c, C
4, IgG and so on were evaluated with ordinary IF technique. Most remarkable findings were as follows: Although in CP, SC and CA membranes, C
3c and IgG were stained lineally along the internal sides of hollow fibers, they were not detected in PMMA membrane. C
1q and C
4 were negative in any membranes. These results may suggest the activation of the alternative complement pathway during hemodialysis with the cellulose membrane. Albumin and fibrinogen were weakly stained in all membranes. In PMMA membrane with FUT-175 or OP-41483, less albumin stain was noted. These results indicate that IF examination is usefull method to evaluate the blood-membrane interaction and the effects of anticoagulants on that.
View full abstract
-
S. INOUE, T. HIRABAYASHI, R. YORIFUJI, O. INAGAKI, H. MORI, Y. FUJITA, ...
1984 Volume 13 Issue 2 Pages
635-638
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We evaluted performance of 11 dialyzers including 9 new memranes. UFR of dialyzers using PS & PAN memranes is highest. KF1N [1.2] & PAN 15 are highest in removal rate of small molecular weight solutes, though are lower in BMG. In contrast, dialyzers using EVA memranes are lowest in removal rate of small molecular weight solutes, though are high permeable to protein. PS-AK has highest performance for all solutes. In conclusion, dialyzers using new membrane are superior in UFR and in removal of β
2-microglobul in and prolact in, but are inferior in removal of small molecular weight solutes to cuprophan membrane. The study on these performance characteristics of new dialyzer membranes may contribute to adequate hemodialysis.
View full abstract
-
T. TAKAGI, T. G. CHUNG, H. OGAWA, A. SAITO
1984 Volume 13 Issue 2 Pages
639-642
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The UFR changes of the protein permeable hemofilters (B1-L, TK-401 and C-2), reduction rate and plasma protein elimination were studied. The UFR distinction between B1-L and TK-401 in the HDF treatment were observed, which was due to the difference of pore size. The decreasing curve for the UFR of TK-401 was much larger than that of Bl-L. The BUN clearance were: TK-401, 189.0mL/min; B1-L, 186.9ml/min; C-2, 130.9ml/min. The CRN clearance were: TK-401, 168.8ml/min; B1-L, 160.1ml/min; C-2, 114.8ml/min.
View full abstract
-
A. SAITO, H. OGAWA, T. TAKAGI, T. G. CHUNG
1984 Volume 13 Issue 2 Pages
643-646
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
This study was conduted to make clear the advantages and disadvantages of elimination of large molecules, mainly of low molecular weight proteins, by using a hemofilter of higher cut-off point than that of conventional one. Ten patients receiving conventional hemodialysis were transferred to hemodiafiltration (HDF) with C-2F, permeating 10g of albumin per HDF and their one year experience is reported. As a result, erythrocyte count and hematocrit significantly increased. Bone and joint pain resulting from osteomalasia of 4 patients improved in all. Serum total cholesterol and HDL-cholesterol increased significantly and serum total protein, albumin and β
2-microglobulin apparently decreased. Residual uremic symptoms such as bone pain and anemia were improved by introduction of HDF using a filter with higher cut-off point.
View full abstract
-
[in Japanese]
1984 Volume 13 Issue 2 Pages
647
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
T. AKIZAWA, T. TAIRA, K. MORIKAWA, E. KINUGASA, T. SEKIGUCHI, T. KITAO ...
1984 Volume 13 Issue 2 Pages
648-651
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We developed activated charcoal beads (Z-Ac) which could adsorb phosphate as well as other uremic solutes. Z-Ac was made from petroleum pitch charcoal beads whose pore surface were equally covered with crystalized zirconium. In phosphate buffer solution, g of Z-Ac adsorbed 5.1mg of phosphate, which indicated that g of zirconium oxide in the charcoal adsorbed 58mg of phosphate. In human plasma, Z-Ac removed 1.25mg of phosphate. Z-Ac seldom adsorbed other electrolytes than phosphate and Ca, and adsorptive ratio for phosphate and Ca was about 10. Zirconium mobilization was not detected even after the 48hr incubation with Z-Ac and human plasma. Z-Ac possessed similar adsorptive capacity for other uremic solutes to that of ordinary charcoal. Z-Ac showed sufficient adsorptive capacity for phosphate and creatinine in direct hemoperfusion with phosphate loaded acute renal failure dogs and also revealed adequate blood compatibility. These results indicate that Z-Ac can adsorb phosphate almost selectively with keeping proper adsorptive capacity of charcoal, and Z-Ac is useful to treat the patients with renal failure.
View full abstract
-
G. TAKAHASHI, O. AKIHIRO, S. AMANO
1984 Volume 13 Issue 2 Pages
652-655
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Old type is one which use collodion coated beed type charcoal of 80gm and Cuprophan hollow fiber. Old type is effection in patient with uremic neuropathy. New type is one which use hydron coated beed type charcoal of 80gm and EVAL-C type hollow fiber. We examined the efficacy to eliminate paraquetion.
View full abstract
-
T. WATANABE, O. OTSUBO, H. KAWAGUCHI, N. AKIYAMA, K. YAMABE, Y. KUROMA ...
1984 Volume 13 Issue 2 Pages
656-659
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We developed a new type of activated charcoal. This material is stick shaped charcoal being made of superior coal, its mean diameter ranging 0.7mm and length ranging 130mm, the effective surface area being 995m
2/gr and macro polus being 0.478ml/gr. In present study, in vitro adsorption of creatinine, uric acid, bilirubin and amino acids were tested with this material. In vivo test of direct hemoperfusion using dogs, changes of blood flow and pressure drop across the column were measured with column of this material. As results of in vitro and vivo tests, it suggests that stick shaped charcoal was similar in adsorbability to conventional bead charcoal and column of this material was able to use DHP without blood pump for no pressure drop in column.
View full abstract
-
S. TAKESAWA, N. ARAI, A. HOTTA, K. SAKAI, K ANDO, T. HONMA, A. YAMASHI ...
1984 Volume 13 Issue 2 Pages
660-663
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
It is important to perform an
in vivo module performance to select an optimum dialyzer for each patient. The correlation between
in vitro and
in vivo performance of dialyzer was investigated. The results show high correlations between
in vitro and
in vivo results on dialyzer clearance C
L and ultrafiltration coefficient UFR. It is possible to estimate
in vivo C
L and UFR from the data of
in vitro C
L and UFR. The estimation of
in vitro performance is a first step toward the clinical use of dialyzer.
View full abstract
-
N. ARAI, S. TAKESAWA, K. SAKI
1984 Volume 13 Issue 2 Pages
664-667
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Frame the point of RBC membrane permeability the possibility of substituting bovine for human blood in estimating mass transfer resistance of a solute was investigated theoretically and experimentally. Urea transfer through both bovine and human RBC membrane is so rapid that conventional clearance could be used. Mass transfer resistance through bovine RBC membrane doesn't allow creatinine transfer easily. Creatinine can transfer slowly through human RBC membrane within the residence time passing through a dialyzer. This difference of permeability causes the disequilibrium between inside and outside of RBC on the venus side of a dialyzer and we overestimate creatinine clearance. This clearance should not be used for estimating the removed amount of a solute.
View full abstract
-
K SAITOH, S TAKEZAWA, K SAKAI
1984 Volume 13 Issue 2 Pages
668-671
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The purpose of this report is to perform the evaluation of hemof ilter with respect to both hydraulic and solute permeability. Hydraulic permeability is usually expressed by filtration coefficient (Lp) and solute permeability by sieving coefficient (SC) of middle molecules. Both values are measured in vitro with aqueous test solution and bovine blood under the same condition. Sieving coefficient is plotted against molecular weight. Blood Lp decreases as transmembrane presure (TMP) increases. Cut off curve obteined from bovine blood experiments is located below that from aqueous solution experiments.
View full abstract
-
[in Japanese]
1984 Volume 13 Issue 2 Pages
672
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
T. HIRABAYASHI, R. YORIFUJI, O. INAGAKI, H. MORI, S. INOUE, Y. FUJITA, ...
1984 Volume 13 Issue 2 Pages
673-676
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The pharmacokinetics of fosfomycin was studied after intravenous drip infusion in 5 patients undergoing hemodialysis. All were chronic hemodialysis patients. Mean fosfomycin clearance by hemodialysis was 124.3±22.2ml/min. Pharmacokinetic parameters were derived using a 1-compartment model. During hemodialysis, the mean distribution volume was 10.16±1.66 1; the mean total body clearance was 5.91±0.75 1/hour; and the mean serum half life was 1.21±0.29 hour. Our results showed that fosfomycin is well dialyzed and that it is entirely eliminated by the artificial kidney on chronic hemodialysis patients.
View full abstract
-
I. KAWATA, J. KOHJINA, S. TAKESAWA, K. SAKAI
1984 Volume 13 Issue 2 Pages
677-680
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The objective of this report is clarify the mechanism of electrolyte transfer through dialysis membrane. The usual dialysance D
B, which was proposed by E. Klein
et al, is valid for nonelectrolytes. However, it has not been investigated if D
B was valid for electrolytes, so that experiments were planned to confirm that in our laboratory. It was found that D
B was not valid for electrolytes in case of protein solution but valid in case of aqueous solution, because protein was anionic in charge and also impermeable to dialysis membrane. It is necessary to take into account the Donnan effect only in the case of protein solution.
View full abstract
-
M. NAMBU, Y. ITO, R. IMAI, S. KUSAKARI, K. KUMANO, T. SAKAI
1984 Volume 13 Issue 2 Pages
681-684
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
One of the biggest advantages of hemofiltration (HF), compared with hemodia lysis (HD), is a better tolerance in the vascular system. A higher total peripheral resistance and/or a milder changes in serum osmotic pressure are reffered to explain the low freqency of symptomatic hypotension during HF. To investgate this advantage of HF in vascular system, plasma catecholamine was measured during HF and HD. Both treatment were designed to match the clearances in small molecular substances. Cold (34°C) dialysate dialysis was also compared to warm (37°C) dialysate dialysis in this study. Although similar mild changes were observed in serum osmotic pressure between HF and HD, the significant reduction in plasma noradrenalin (NA) concentration was noticed on HD, however there was no significant change on HF. NA was decreased significantly also in “warm” dialysis, but no change was observed in “cold” dialysis. NA was confirmed to be removed in the same degree in these treatment. These data force to conclude that HF and cold dialysate dialysis stimulate adrenergic system more than the conventional dialysis, which can be one of the reasons for a better tolerance in vascular stability.
View full abstract
-
Fumiyoshi NAKAYAMA, Yutaka NAKAJIMA, Katsuhiko TAMURA, Hiroomi KOJIMA, ...
1984 Volume 13 Issue 2 Pages
685-688
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Although transient leukocyte depletion during hemodialysis (HD) is well known as hemodialysis leukopenia (HL), leukocyte function in HL is not fully evaluated. We examined leukocyte function during HD with chemiluminescence (CL), which was an excellent marker of leukocyte activity, and estimated the effect of membrane materials and anticoagulants on CL. CL/WBC was not suppressed in the patients under hemodialysis, with nephritis nor in the end-stage renal failure compared with that of healthy control. CL/WBC decreased remarkably during HD with cuprophan and saporified cellulose membrane concomitantly with HL. CL/WBC did not reduce during HD with PMMA and cellulose acetate membrane. CL/WBC in the venous side of dialysis was less than that in the arterial side. The degrees of lowering of leukocyte activity in HL was equal in HD with various anticoagulants, namely heparin, MD-805 (specific thrombin blockade), FUT-175 (multi-enzymatic inhibitor) and PG analogue. These results indicate that leukocyte function is suppressed in HL and the evaluation of leukocyte activity with CL is useful method to estimate the blood compatibility of membrane materials.
View full abstract
-
I. IIZUKA, Z. YAMAZAKI, F. KANAI, M. HIRAISHI, T. WADA, T. TAKAHAMA, Y ...
1984 Volume 13 Issue 2 Pages
689-692
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Dialyzers made of cellulose, PAN, PMIVIA and EVAL were evaluated as to their effects on the coagulation and fibrinolytic systems.
90minutes of extracorporeal circulation using these dialyzers were carried out on dogs, and APTT, factor XII, fibrinogen, plasminogen and α
2 plasmininhibitor were examined.
Results. A-PTT was almost unchanged or slightly elongated. Each factor showed mostly 10-30% decrease. Cellulose dialyzer showed somewhat slighter decrease of the factors than the other dialyzers made of synthetic membranes.
View full abstract
-
[in Japanese]
1984 Volume 13 Issue 2 Pages
693
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
H. SHINTANI, K. TSUJI, T. OBA
1984 Volume 13 Issue 2 Pages
694-700
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Removal of serum uremic toxins, especially urea, using ion exchange resins was previously reported by us. The major problem of this procedure was balancing pH and cations after passing serum through the resin. Varying the mixing ratio of Amberlite 200C and Amberlite 50 of various ion—types, the amount of Na, K, Ca, and Mg and pH were determined before and after passing 50ml of serum through the mixed resin bed. The following ratio of resins was suitable to balance pH, K, Ca and Mg: 0.3ml of Amberlite 200C(H), 0.18ml of 50(K), 0.21ml of 50 (Mg) and 0.75ml of 50 (Ca). However, about 16% of Na could not be recovered even when increasing the volume of Amberlite 200C (Na) to 5ml. Amount of urea adsorbed was increased when increasing volume of 200C (Na). The amount of serum Na, K, Ca and Mg determined by ion chromatography, ion selective electrode, colorimetry and atomic absorption spectrometry were compared one another. Ion chromatography was suitable for determination of totaling free and bound cations, and free cations, respectively.
View full abstract
-
T. OUMI, T. NAKAMURA, S. NAKASE, T. HASHIMOTO, H. HASEBE, M. AHAGON, F ...
1984 Volume 13 Issue 2 Pages
701-704
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Sodium lactate, usually used for correcting acidosis, is composed of both L-lactate and its optical isomer, D-lactate. Since D-lactate is nonphysiological isomer and hence it has some disadvantages such as a slower rate of metabolism and its peculiar metabolic pathway, a new set of questions have been casted on its usefulness and safety. Thereforewe investigated the effects of L-lactate containing solution (L-group) and D, L-lactate one (D, L-group) when used in the hemofiltration method and evaluated the concentrations of lactate both in the blood and the ultrafiltrate, the faculty of correcting acidosis, the total amount of loading and the availability of lactate between two groups. As for acid-base balance, a significant alkalization effect was noted in two groups, but its effect was better in the L-group than that of the D, L-group. The concentration of the total lactate in the blood and the ultrafiltrate were higher in the D, L-group than L-group, the amount of consumed lactate in the body was more and its availability was excellent. Therefore, L-lactate was considered to be better physiological alkalyzing solution to load much amount of lactate during a short time.
View full abstract
-
H MISAWA, H NAGAI, T BIRUMACHI, T ISHIYAMA, T MIKAMI, N UENO, Y HUKUDN ...
1984 Volume 13 Issue 2 Pages
705-707
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Hemodialysis with Ca free dialysate was evaluated as an assist of regional anticoagulation. Dialyzers used in this were KF101 (Kuraray), B
2100 and B
2200 (Toray Medical). Dialysate composition was as follows: Na 132mEq/L, K2.0mEq/L, Cl100.5mEq/L, Mg1.5mFq/L, CH
3COO35mEq/L and glucose 200mg/dl. In hemodialysis with the conventional dialysate, Kaolin activated whole blood clotting time (KCT) was shortened after the dialyzer. On the contrary, serum Ca level was reduced and KCT was prolonged significantly in hemodialysis with Ca free dialysate. Reduction rates of serum Ca were 60 to 80%, Two percent CaCl
2. solution was continuously infused from venous line to correct serum Ca. In hemodialysis with the conventional dialysate, clotting in the extracorporeal circulation was observed when heparin doses were reduced to 600 to 200u/hr. Despite with the same heoarin doses, the clotting was conquered when conventional dialysate was replaced by Ca free dialysate. In conclusion, Ca free dialysate is a useful assist of regional anticoagulation.
View full abstract
-
M. ONOHARA, T. KUNITOMO, S. NISHIUM, F. INAGAKI, H. SUGISAKI
1984 Volume 13 Issue 2 Pages
708-713
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
To elucidate behaviors of phosphorus compounds including inorganic phosphate (Pi) which may be closely linked with bone metabolism, efflux of Pi from and
31P NMR spectra of RBC were measured. Efflux of Pi from RBC into dialyzed plasma or saline lasts even after outer Pi concentration exceeds the original plasma Pi level, which suggests the Pi transport not controlled only by simple diffusion and the existence of Pi precursor (s) in RBC.
31P NMR spectra of RBC from dialysis patients reveal that it contains ATP and maybe sugar phosphate (SP) more than that from normal subjects and that 2, 3-diphosphoglycerate and SP are main precursors of Pi efflux from RBC.
View full abstract
-
T. YAMAMOTO, N. HORIUCHI, S. HIRATA, N. KASHIWARA, H. NISHITANI, Y. MI ...
1984 Volume 13 Issue 2 Pages
714-716
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Acetate is considered one of the factors causing hypotension in hemodialysis (HD). Normalization of acidosis and vascular stability could be better achieved by HF with acetate containing substitution fluid. Therefore, comparative study on acetate kinetics was carried out between HF and HD. 7HF patients were selected for this study. The data of acetate kinetics on HD patients was quoted from our previous study. Acetate kinetics was calculated from removed HCO
3-(Rbc), generated HCO
3- (Gbc), loaded CH
3COO- (Lac) and convert rate from acetate to bicarbanate (OR). The results were as follows: Rbc were 99±17 (HF) and 114±23mmol/hr (HD). Gbc were 137±18 (HF) and 128+27mmol/hr (HD). Lac were 142±25 (HF) and 162+27mmol/hr (HD). CR were 98±18 (HF) and 79+91 (HD). Gbc was quite similar in both HF and HD in spite of the lower amount of Lac. Lac was almost completely converted to bicarbonate in HF. The above results suggest that acetate metabolism is performed more efficiently in HF, and permits better compensation of acidosis and less increase in serum acetate concentration which leads to more stability of the cardiovascular system.
View full abstract
-
N. MATSUI, Y. FUKUDOME, S. NAKAGAWA, K. OTA
1984 Volume 13 Issue 2 Pages
717-719
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
MD805 was highly concentrated by dissolving in acidic ethanol solution in order to be used as a hemodialysis anticoagulant. The anticoagulant effect of highly concentrated solution was almost equal to the previous diluted solution. Low pH did not influence the acid—base balance. Serum ethanol level did not increased after a single procedure of hemodialysis because of a small dose and high dialysability. Hemolysis or other adverse effects were not observed through the test period. In conclusion, highly concentrated solution of MD805 is a useful anticoagulant for hemodialysis.
View full abstract
-
[in Japanese]
1984 Volume 13 Issue 2 Pages
720
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
M TATEYAMA, I ISHIZAWA, T ONODERA
1984 Volume 13 Issue 2 Pages
721-723
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We calculated the quantity of the dialysate that went out from the dialysis and came into it by a fixed quantitie s container and we developed quantitative ultrafiltration volume measure monitor (T—model 24) that we measured the ultrafiltration volume by the difference this mechanism can moasure ultrafiltration within 20ml pereach hour and also can joint use every kinds of the dialysate and can application HDF that is multi perpass ultrafiltration volume measure monitor
View full abstract
-
T. ISHIHARA, H. INAGAKI, I. IGARASHI, T. KITANO, K. MAEDA, T. SHINZATO ...
1984 Volume 13 Issue 2 Pages
724-727
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
A program control system of circulating blood volume during hemofiltration has been developed, which is constructed from a continuous circulating blood volume measuring system, a micro-computer, and a substitution fluid infuser. In this system, hematocrit is calculated from the formulae as a function of electrical resistivities of blood and filtrate, which was given by Geddes and Gram. Then the circulating blood volume change, ΔBV, is calculated and the flow rate of the infuser is adjusted by the micro-computer. This system was applied to 8 patient in a total of 30 times and was found to keep the difference between actual and desired blood volume values within ±3%.
View full abstract
-
K. MAEDA, R. SEZAKI, T. SHINZATO, M. USUDA, F. YOSHIDA, Y. TSURUTA, K. ...
1984 Volume 13 Issue 2 Pages
728-731
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The continuous hematocrit detector has been developed. It contains four electrodes and a thermistor in the extracorporeal blood circuit and detects hematocrit by means of blood electrical resistivity. As there is the functional relation between the difference of hematocrit and the difference of blood volume, the difference of plasma volume can be monitored continuously. Automatic plasma volume regulator consists of a blood pump, hematocrit detector, a hemofilter and substitution fluid supply pump in an extracorporeal blood circuit, an electrical resistivity detector in the ultrafiltrate compartment of the hemofilter, and a microprocessor for controlling substitution fluid supply pump. The automatic plasma volume regulator has been applied seven times to control the plasma volume of four regular dialysis patients. Measured plasma volume by blood electrical resistivity detector fitted the predicted plasma volume curve acculately. The automatic plasma volume regulator can be applied not only to the dialysis patients but to the many patients under intensive care.
View full abstract
-
Y. YAMASAKI, Y. IWAI, Y. IRITANI, N. KASHIHARA, Y. TATUMI, S. YAMAGAMI ...
1984 Volume 13 Issue 2 Pages
732-734
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We have developed an on-line supplying device of substitution fluid which consists of a tap water purification system using R-O and OF filter, a mixer which dilutes the concentration with purified water and a OF filter system for pyroqen. This system can provide large amounts of high quality substitution fluid at lower costs compared to the conyentional was and eliminates the trouble of exchanging the bottle or bag and the contamination caused during the exchanges, simplifying the process and providing safer treatment.
View full abstract
-
J. KOHJINA, K. OZAWA, S. TAKESAWA, K. SAKAI, A. YAMASHITA, H. ICHIHARA ...
1984 Volume 13 Issue 2 Pages
735-738
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The improvement in hemodialysis (HD) treatment has been done, but the recent treatment is not necessarily perfect. WADIC is now being developed in our laboratory to treat each chronic renal failure patient satisfactorily. WADIC can measure the concentrations of urea nitrogen (UN), creatinine and MM in outlet dialysate. Integration of outlet dialysate concentration (C
D) during the treatment will give the total amount of removed solute (M). UN and creatinine concentration in blood may be estimated from C
D by using the principle of mass balance. In our WADIC system, the remove amount of water (ΔV
T) may be controlled just by the change of transmembrane pressure. WADIC can can also control the treatment time and select the suitable type of dialyzer for each patient by following up C
B, ΔV
T and M all through HD treatments.
View full abstract
-
Y. KITAMOTO, Y. TAGUMA, H. MOMMA, M. TSHIZAKI, H. TAKAHASHI, H. SEKINO ...
1984 Volume 13 Issue 2 Pages
739-742
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
The treatment with ultrafiltration is effective in rerrnving excess fluid of overhydrated patients secondary to nephrotic syndrome, chronic renal failure, congestive heart failure or liver cirrhosis. We report here a 34- year- old man suffering from steroid resistant nephrotic syndrome due to membranous and diabetic nephropathy. He gained 20kg during 2 months since admission, in spite of various treatment and suffered from dyspnoea and abdominal pain. Twenty- nine litre of fluid was ultrafiltrated under supplementation of colloidal fluid by 6 trials in 7 days. Hemodynamic changes were observed using Swan- Ganz thermodilution catheter. After each treatment, colloidal osmotic pressure increased and hematocrit value decreased, suggesting the efficient transfer of extracellular fluid into blood vessel and expansion of circulating blood volume. Cardiac function did not change during fluid removal below 4 litre. After the fluid removal of 7 litre, CI and PCWP decreased 12% and 12mmHg each. LVSWI SVR and PVR increased 13%, 36% and 31% individually. MAP did not change significantly. GFR decreased 28%. General condition of the patient is extremely improved after the treatment.
View full abstract
-
[in Japanese]
1984 Volume 13 Issue 2 Pages
743
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
-
I AMANO, Uichi MORI
1984 Volume 13 Issue 2 Pages
744-747
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We made a new wearable catheter (type IL) as temporary access. The catheter, made of heparin coated polyurethan, was used clinically in 390 patients. No important complication was found in use of the catheter. The catheter is usefull as temporary blood access of hemopurification.
View full abstract
-
I. AMANO
1984 Volume 13 Issue 2 Pages
748-750
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Our new method of A-V fistula at upperarm is the utility of mobilized basilic vein subcutaneously. We experienced our new method in 69 hemodialysis patients. Patencies of the functionning period is percent of 72 in 2 years, and percent of 50 in 4 years. Few complications such as infection were found in our new method.
View full abstract
-
Y. INAGAKI, M. TSUYUKI, T. YAMAMOTO, I. AMANO, S. SUGIYAMA, M. ITOH, T ...
1984 Volume 13 Issue 2 Pages
751-755
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Flexible single and double lumens (FSL and FDL) catheters were designed as temporary blood accesses for the patients with shunt trouble, acute renal failure and other diseases. They are made of silicone rubber which has superior anti-coagulability, and sufficient blood flow is obtained through them. New micro-pumps were developed to inject heparin continuously. The lumens of the catheters were prevented from clotting, using less than 1200 unit of heparin in most cases. Bleeding accident was not observed in our cases by using the tube with one way valve and lock type connection. As a result, FSL and FDL catheters were used safely. Patients with these catheters can walk freely and regain daily activity.
View full abstract
-
M. ANDOH, S. SHIRANE, S. KUROKAWA, F. UNO
1984 Volume 13 Issue 2 Pages
756-759
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
We made prototype machines WAK-II and III in cooperation with Prof. Kolff of Utah Univ., and had successful clinical results. This time, we have developed a portable artificial kidney system PKS and PMS. The dimension of PKS is W170, D115, H200(m/m) and its weight is 2.9kg. PMS has the size of W170, D220, H550 and weighs 14kg. These can be made lighter in the future. PKS is of a double power source type, and dialysis can be performed by using a battery in an emergency and disaster. When combined with PMS, since fixed facilities and pipings are not necessary at all, it is possible to carry out dialysis without restrictions by time and space.
View full abstract
-
M. MINESHIMA, N. SUDO, M. TAKEMOTO, M. HASUO, E. ADACHI, T. SUZUKI, K. ...
1984 Volume 13 Issue 2 Pages
760-763
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Newly defined characterization parameters, namely, time-averaged clearance (C
L) and concentration (C
S) in stable periods, are introduced into the comparison of removal dynamics in several hemopurification modalities. These parameters are calculated from the solute concentrations by compartment model. As a result, the solute generation rate (G) of low molecular metabolites in six CAPD patients decreases at 20-30% of the value obtained when the patients were treated with HD. Molecular weight (MW)-C
L profile in CAPD is similar to that in HF, but MW-C
S profile in CAPD is similar to that in HDF because of the reduced G in low molecular metabolites.
View full abstract
-
R. SAKAI, M. NISHIOKA, K. KOMABA, J. SHIN, S. SHINKO, Y. EIJITA, S. IN ...
1984 Volume 13 Issue 2 Pages
764-767
Published: April 15, 1984
Released on J-STAGE: October 07, 2011
JOURNAL
FREE ACCESS
Comparative studies between CAPD group (6 patients, underwent for over 8months) and PLED group using EVAL-C membrane (6 patients, underwent for 5 months) were performed. Elevation of Triglyceride, Cholesterol, Fibrinogen and α
2-globulin were observed in both groups. These findings are consistent with nephrotic pattern attributed to protein loss. HDL-Cholesterol remained unchaged and BMG decreased in both groups. Blood pressure lowered in CAPD and rose in PLHD. Increase in Ht was observed in CAPD. Quite different pattern was observed in PT, APTT and ATIII in both groups. It was shown by PAG electropheresis that PLHD and CAPD were common in respect of protein losing but were somewhat differant in behavior of protein loss. From these studies, PLHD was not highly evaluated compared to CAPD. However, PLHD should be further employed to find out unique features and benificical effects in comparison with CAPD.
View full abstract
