Abstract
This study was conduted to make clear the advantages and disadvantages of elimination of large molecules, mainly of low molecular weight proteins, by using a hemofilter of higher cut-off point than that of conventional one. Ten patients receiving conventional hemodialysis were transferred to hemodiafiltration (HDF) with C-2F, permeating 10g of albumin per HDF and their one year experience is reported. As a result, erythrocyte count and hematocrit significantly increased. Bone and joint pain resulting from osteomalasia of 4 patients improved in all. Serum total cholesterol and HDL-cholesterol increased significantly and serum total protein, albumin and β2-microglobulin apparently decreased. Residual uremic symptoms such as bone pain and anemia were improved by introduction of HDF using a filter with higher cut-off point.
