Abstract
We developed activated charcoal beads (Z-Ac) which could adsorb phosphate as well as other uremic solutes. Z-Ac was made from petroleum pitch charcoal beads whose pore surface were equally covered with crystalized zirconium. In phosphate buffer solution, g of Z-Ac adsorbed 5.1mg of phosphate, which indicated that g of zirconium oxide in the charcoal adsorbed 58mg of phosphate. In human plasma, Z-Ac removed 1.25mg of phosphate. Z-Ac seldom adsorbed other electrolytes than phosphate and Ca, and adsorptive ratio for phosphate and Ca was about 10. Zirconium mobilization was not detected even after the 48hr incubation with Z-Ac and human plasma. Z-Ac possessed similar adsorptive capacity for other uremic solutes to that of ordinary charcoal. Z-Ac showed sufficient adsorptive capacity for phosphate and creatinine in direct hemoperfusion with phosphate loaded acute renal failure dogs and also revealed adequate blood compatibility. These results indicate that Z-Ac can adsorb phosphate almost selectively with keeping proper adsorptive capacity of charcoal, and Z-Ac is useful to treat the patients with renal failure.
