Effects of dialyzers on the coagulation and fibrinolytic systems

Abstract

Dialyzers made of cellulose, PAN, PMIVIA and EVAL were evaluated as to their effects on the coagulation and fibrinolytic systems.
90minutes of extracorporeal circulation using these dialyzers were carried out on dogs, and APTT, factor XII, fibrinogen, plasminogen and α₂ plasmininhibitor were examined.
Results. A-PTT was almost unchanged or slightly elongated. Each factor showed mostly 10-30% decrease. Cellulose dialyzer showed somewhat slighter decrease of the factors than the other dialyzers made of synthetic membranes.