Abstract
MD805 was highly concentrated by dissolving in acidic ethanol solution in order to be used as a hemodialysis anticoagulant. The anticoagulant effect of highly concentrated solution was almost equal to the previous diluted solution. Low pH did not influence the acid—base balance. Serum ethanol level did not increased after a single procedure of hemodialysis because of a small dose and high dialysability. Hemolysis or other adverse effects were not observed through the test period. In conclusion, highly concentrated solution of MD805 is a useful anticoagulant for hemodialysis.
