局所抗凝固剤としてのFUT-175のDHPへの応用

岡 藤太郎; 谷 徹; 花沢 一芳; 橋本 宇史; 遠藤 善裕; 吉岡 豊一; 角田 富士男; 中根 佳宏; 小玉 正智

doi:10.11392/jsao1972.13.1222

Fundamental studies on FUT-175 for direct hemoperfusion

T. OKA, T. TANI, K. HANASAWA, T. HASHIMOTO, Y. ENDO, T. YOSHIOKA, F. TSUNODA, Y. NAKANE, M. KODAMA

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T. OKA
1st Dep. of Surg. Shiga University of Medical Science
T. TANI
1st Dep. of Surg. Shiga University of Medical Science
K. HANASAWA
1st Dep. of Surg. Shiga University of Medical Science
T. HASHIMOTO
1st Dep. of Surg. Shiga University of Medical Science
Y. ENDO
1st Dep. of Surg. Shiga University of Medical Science
T. YOSHIOKA
1st Dep. of Surg. Shiga University of Medical Science
F. TSUNODA
1st Dep. of Surg. Shiga University of Medical Science
Y. NAKANE
1st Dep. of Surg. Shiga University of Medical Science
M. KODAMA
1st Dep. of Surg. Shiga University of Medical Science

Keywords: FUT-175, 6-Amidino-2-Naphthyl-4-Guanidinobenzoate Dimethanesulfonate, Anticoagulant, Anion Exchange Fiber, Hemoperfusion

JOURNAL FREE ACCESS

1984 Volume 13 Issue 3 Pages 1222-1225

DOI https://doi.org/10.11392/jsao1972.13.1222

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Abstract

The adsorptions of FUT was syudied nn seven adsorbents in vitro. XAD-7, 8 adsorbed almost all FUT From the FUT solution, although Anion Exchange Fiber (AEF) and IRA-938 did not. XAD-2, 4 and PNEMA coated activated charcoal (DHP-1) had a small capacity. AEF and DHP-1 were exsperimented ex vivo. DHP (AEF) succeeded safely with 20-40mg/hr infusion of FUT. DHP-1 could not be used with 15-60mg/hr FUT.

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