Abstract
Newly developed substitution fluid for bicarbonate hemofiltration(BCHF) is consist of solution A and B. A contains NaCl, KCl and NaHCO3, and B contains CaCl2, MgCl2, glucose and Na-acetate. For the usage, they should a mixed at the ratio of A;B=100:1 manually. Final composition of the mixed fluid is as follows: Na 140.0, K 2.0, Ca 3.5, Mg 1.0, Cl 111.0, HCO3 35.0, CH3COO 0.5mEq/l, glucose 100mg/dl and PH 7.35. The concentration of solutes nd pH in the mixed fluid did not change at least for 24 hours. In the clinical studies, BCHF prevented many disequilibrium symptoms, corrected electrolyte disturbances and removed uremic substrates sufficiently during therapy. It was calculated that about 150mEq of HCO3 and 10mEq of Ca flew into the body during each BCHF. No side effects were observed in the course of 5 months BCHF. These results indicate that this solution is very simple for preparation and has many beneficial effects on the treatment of renal failure.
