Artificial pancreas ----- Experimental usee of subcutaneous glucose sensor in a dog

Abstract

The new glucose sensor for subcutaneous tissue is being developed by our group. The shape of this sensor which has glucose electrode and reference oxygen electrode is stick-like, and it is implanted into subcutaneous tissue. The sensor detects tissue fluid glucose which corresponds to blood glucose, and responses to tissue fluid glucose immediately after loading glucose intravenously. However, it takes about 2 minutes to detect the peak of tissue fluid glucose. There is good correlation between tissue fluid glucose value by the sensor and blood glucose value by ordinary glucose autoanalyzer.