Long-term glycemic controls in insulin-dependent diabetics with a wearable artificial endocrine pancreas

Abstract

Ambulant insulin-dependent diabetics were controlled with the wearable artificial endocrine pancreas to evaluate its feasibility. When the needle-type glucose sensors were kept in subcutaneous tissue for 72hrs, “relative” sensor outputs were depressed (73.5%), and “relative” sensors' response times were elongated from 5.1 to 13.5min. Perfect glycemic controls for up to 6 days were obtained with the system by replacing a sensor at the 4th day. These data indicated the feasibility of the long-term control with the system.