Abstract
An extracorporeal circulation system for plasma exchange (PE) was developed in cancer bearing rats model. After removing of various immunosuppressive factors in the sera of cancer bearing hosts using PE, adequate immunochemotherapy was performed. We studied the roles of PE in augmenting efficacy to immunochemotherapy and the changes of immunosuppressive factors in the sera. Immunosuppressive substance, AFP level and PHA inhibitory factors were increased gradually in the sera along with the tumor development from fifth or sixth day after tumor inoculation. After P E performed PHA inhibitory factors and AFP level in the sera were adequately decreased compared with those before PE performed. On the case that chemotherapy was administered after PE, the survival of those group was significantly better than that of chemotherapy alone group.
On the case that OH-1, the lymphokine, which possess anti-tumor effect, was administered after PE, the anti-tumor effect of OH-1 alone group was significantly better than that of control group, and these effect of PE+OH-1 group was further better than that of OH-1 alone group. The effectiveness of immunochemotherapy in cancer bearing host is augmented by removal of the immunosuppressive factors using PE.
