Abstract
Immunological changes during DFPP were discussed in 7 patients with rheumatoid arthritis. reduction of immunoglobulins were observed at post treatment, and after 4th treatment. Leukocytosis were observed at post treatment. A increase of OKT4 and OKT4/OKT8 ratio were observed at post treatment. OKT4 and OKT8 decreased slightly after 4th treatment. Thease phenomena suggest that changes of cell mediated immunological processes occurs during DFPP therapy.