Abstract
The effect of plasma separation on with membrane type plasma separator on the red blood corpuscle (RBC) was evaluated by the changes of hemoglob in absorbance of the filtrate.
The effect of transmembrane pressure (TMP) was also evaluated. The membranes of the separator investigated were cellulose diacetate (CA) and polyvinylalcohol (PVA). There was no difference between the inlet and the outlet of the separator in the hemoglobin concentrations, both in CA and PVA. In case of CA, however, hemoglobin absorbance was slightly increased to the increase of TMP, indicating the destruction of RBC. This change was not identified in PVA.
The hemolysis associated with plasma separation is sometimes difficult to detect, especially when it is with a small amount. The application of hemolysis detection by hemoglobin absorbance makes it possible in the early phase of its occurance.
