Abstract
In order to know the mechanism of copolymer of ethylene and vinyla cohol (EVA) membrane anti-thrombogenic characteristics, the extract from the dialyzer membrane was injected into rabbits and the changes of platelet aggregability before and after the administration were studied. Ethylene alcohol 500ml circulated through the dialyzer was collected. The solution was condensed to 2ml by evaporator. This condensed solution was injected into New Zealand white rabbits by 0.5ml/days. The control group was same amount of ethylene alcohol solution was treated for ten days. ADP 10μM, collagen 10μg, arachidonic acid (AA) 1.0mM and 2.0mM were used for determination of platelet aggregability. No particular changes of platelet aggregability were observed in the control group. The extract administered group a significant decrease in platelet aggregability induce by ADP 10μM after the administration than before (p<0.05, n=5). Although not significant, platelet aggregability induced by AA 1.0 and 2.0mM shows a tendency of decrease after administration than before. The extract from the circulated solution through the dialyzer made of EVA had a decrease in the platelet aggregability in New Zealand white rabbits, thus suggesting that EVA membrane has an inhibitory effect on platelet aggregability.
