5PM3-PMN-031 Long-term Evaluation Of Micro Hemodialysis System

Abstract

Nano porous polyethersulfone (PES) membrane is a competent material for nanofiltration such as purification, fractionation and dialysis. We have ever been developing micro hemodialysis system containing this PES membrane. However, when blood was used in this dialysis system for long time, platelets adhesion occurred on the surface of membrane and its performance degraded. In this work, we coated fluorinated diamond-like carbon (F-DLC) on PES membrane to modify its surface. We investigated anticoagulant F-DLC/PES membranes with a micro fluidic device and experimentally found that the amount of cells attached to the surface thoroughly reduced by coating F-DLC. We also conducted long-term experiments for 1 week and the performance was found to deteriorate because of fouling without coating F-DLC.