Hemodynamic, Physiological and biochemical responses to LVAD pumping

Abstract

In order to evaluate the biological responses to LVAD pumping, LVAD was applied to goats and mongrel dogs that were induced with left ventricular failure (LVF) by multiple ligations. Total Flow (cardiac output+bypass flow), AoP, systemic vascular resistance and myocardial tissue blood flow were maintained within normal range by LVAD pumping. Left ventricular end-diastolic volume, stroke volume, stroke work and ejection fraction were markedly decreased by LVAD pumping. In chronic experiments, however, there were no noticeable changes in biochemical study. So LVAD can maintain normall circulation even in profound LVF.