Abstract
Rebound of inorganic phosphate (Pi) in plasma is observed not only after dialysis (HD) but also during HD. To pinpoint Pi reservoir (s) involved in Pi rebound during HD and to better control Pi removal by HD, in vitro and in vitro (rat and clinical) tests were performed. Muscles and calvaria harvested from rat were used in in vitro experiments. Not specific but rather general tissues or organs including skeletal muscle are suggested to function as Pi reservoirs. It is also demonstrated that the outflow of Pi from those reservoirs increases as the decrease in Pi concentration in the extracellular fluid and the increase in Pi removal rate by HD. Mild removal of Pi by HD seems to be desirable fromm the viewpoint of preventing unnecessary disturbance to Pi homeostasis.
