An artificial blood Fluosol-DA (FDA) has been reported to be superior to conventional IV fluid in capacity of carrying oxygen to peripheral tissues. In this study, 22 mongrel dogs were divided into two groups: FDA group including 12 animals using FDA as the priming solution and control group including 10 animals using homologous blood. After 90 minutes' deep hypothermic low-flow cardiopulmonary bypass (about 40ml/kg/min) at 20°C, hemodynamics, blood gas, tissue oxygen tension and serum lactate and pyruvate levels were determined. No significant inter-group difference was seen in mean arterial pressure, perfusion rate or total systemic vascular resistance. Analysis of whole-body oxygen consumption, oxygen delivery, oxygen extraction ratio revealed superiority of FDA group to control group in oxygen supply. The oxygen tension as determined at the left upper limb muscle was significantly higher for FDA group throughout the extracorporeal circulation. No consistent tendency was seen in liver oxygen tension. Serum lactate tended to be higher for the control group, while no significant difference was seen in serum pyruvate. From these findings, it was revealed that oxygen exchange in the peripheral tissue is maintained well even under deep hypothermic low-flow cardiopulmonary bypass, indicating the possibility of application of FDA for deep hypothermic extracorporeal circulation.
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