An Experimental study of ECMO with intermittent administration of OP41483 (PGI₂ deliverate)

Abstract

Studies were made on dogs with severe respiratory failure induced by transtracheal administration of Linoleic acid. The dogs were separated into the 4 groups: GI: respiratory failure GII: pumpless A-V bypass GIII: V-A bypass GIV: V-A bypass with administration of OP41483 (PGI₂ derivatives). The dogs in which ECMO was done maintained good blood gas and survived significantly longer than G-I. GIII survived significantly longer than GII. TxA₂ increased and PGI_2/TxA2 ratio decreased after Linoleic acid administration OP-41483 dilated the vessels of lung, and then intrinsic PGI₂ increased significantly and PGI₂/TxB₂ ratio increased following administration of OP-41483. But no significant difference was observed in survival time between GIII and GIV.