A BASIC STUDY ON CARDIOPULMONARY BYPASS, WITH SPECIAL REFERENCE TO THE UNPHYSIOLOGICAL ENTITIES ANALIZED BY TRANSITION OF COMPLEMENT LEVEL

Abstract

Transition of serum complement level was determined in 20 cardiac patients undergoing cardiopulmonary bypass, for better understanding of unphysiological entities in this artificial perfusion. No significant difference was noted in C3, C4, C5, CH50 level between the membrane and bubble oxygenator groups. C3a level in the bubble oxygenator group tended to be higher than that in the membrane group. The higher level in the former group was more prolonged than in the latter, Elevation of C5a level and neutropenia induced during cardiopulmonary bypass with the membrane oxygenator was more dominent than that induced with the bubble oxygenator. In conclusion, the followings would be suggested:1) C3a level is more intentively affected by the blood-oxygen interface than the blood material interaction, and2) C5a level and neutropenia are more strongly affercted by the blood-material interaction than the blood-oxygen interface.