Abstract
This study was performed to make clear the effects of protein permeable hemodiafiltration (PPHDF) on the uremic symptoms such as severe renal anemia, bone pain, and peripheral neuropathy, which had not improved by conventional hemodialysis. And concerning to anemia, the combined effect of anabolic steroid and PPHDF was also examined. As a result, one of three patients with severe renal anemia, two of three patients with bone pain, and one patient with peripheral neuropathy improved by PPHDF. The anemia of two patients, not improved by PPHDF alone, markedly improved by the combined therapy with anabolic steroid. Furthermore, the anemia of four patients, not responded to anabolic steroid for more than five months, improved in all patients by the combination therapy with PPHDF. From these findings, we can conclude that this combined therapy of anabolic steroid and PPHDF, the former increases erythropoiesis in bone marrow and the latter eliminates inhibitory factors of erythropoiesis, is very effective on severe renal anemia.
