Abstract
Since the first description of aliminum-related encephalopathy in patients on regular dialysis treatment, toxicity of alminum is well recognized. Another aluminum-related diseases such as vitamin D resistant osteomalacia and microcytic anemia were also reported. In the present study, as a new non-aluminum phosphate binder, hydrous cerium oxide, a rare earth compound, was investigated. Cerium oxide and hydroxyaluminum were mixed at the ratio of 1.0g/l in solution of phosphate compounds in which phosphate ion concentrations were 2.0mM and stirred for one hour. Cerium and alumina were also compared around neutral range.
The adsorptive effect of cerium oxide was fourth as much as that of hydroxyaluminum. Direct hemoperfusion was performed with cerium oxide column in acutely induced hyperphosphatemia dog. The serum phosphate concentrations declined from 16.7mg/dl to 4.5mg/dl until 60 minutes. Also calcium concentrations declined from 3.8mEq/l to 1.2mEq/l. In conclusion, alternative phosphate binderr in place of aluminum gel is in emergent need and this substance is worth being studied and tested further.
