Pharmacokinetic study on removal of aluminum (Al) from dialysis (HD) patients by desferrioxamine (DFO) and HD

Abstract

Al removal was studied as a test case of removal of deposited solutes by combining extracorporeal procedure with medication. 1) 1: 1 complex formation between DFO and Al in H₂O was confirmed by FAB-MS. 2) DFO in blood and dialysate can be analyzed by HPLC using reverse phase column. 3) Increase in plasma Al induced by DFO infusion significantly correlates with duration of HD. 4) Al and DFO permeability of a protein-leaking membrane is higher than that of a conventional membrane. 5) Following its rapid drop soon after DFO infusion, the plasma DFO levels off and the formation of the stable Al-DFO complex is suggested.