Abstract
Ligature of both ureters was done in mongrel dogs to study the feature of BBB in renal failure. The dogs were divided into two groups: Serum (S) and Cerebro-spinal fluid (C) were obtained daily in one group and during hemodialysis (HD) performed in the fourth day in another group. Electrolytes, BUN, Cr and Osmotic pressure (Osm) of S and C were measured in both groups. Na and Cl in S and C were changed in same direction. Although S-K and S-Ca and S-P were changed greatly, the changes of C-K, C-Ca and C-P were very small. S-BUN was decreased more significantly compared to C-BUN during HD and this phenomenon resulted in the following conditions: S-BUN<C-BUN and S-Osm<C-Osm. S-Cr was changed greatly but the change of C-Cr was very small. These features of the BBB are thought to relate with uremic encephalopathy, dialysis disequilibrium syndrome or dialysis dementia.
