Abstract
A case of IgD. λ myeloma was described. A 59-year-old man was admitted to Kyushukoseinenkin Hospital on July 22 with complaint of lumbago since early June, 1974.
The electrophoresis revealed a M-protein of IgD. λ in serum and λ-Bence Jones protein in both serum and urine.
The administration of cyclophosphamide resulted in a rapid improvement of symtoms and laboratory findings, and the patient lived for 22 months after the onset of symptoms. The survival time of this case was much longer comparing with the mean survival of the patients with IgD myeloma. During the clinical course distinct correlative fluctuations were observed in myeloma cell count, serum IgD level and urinary protein amount.
The renal tissue of the patient obtained at autopsy was subjected to the direct immunofluoresent staining procedure using the antisera for immunoglobulins, λ-chain, fibrinogen and C3. The indirect method was also employed for κ-chain. Predominant staining for λ-chain was observed in tubular casts and no specific glomerular fluorescence was observed.
