DEVELOPMENT OF ARTIFICIAL KIDNEY WITH REGENERATIVE DIALYSATE USING UREA ADSORBENT

Abstract

With a view to eliminating urea, the most important point which has so far been considered from the viewpoint of miniaturizing the artificial kidney, we have developed a urea adsorbent composed of an enzyme (urease) and an inorganic adsorbent. As an approach to an artificial kidney of portable and wearable type, we have devised an artificial kidney system with regenerative dialysate using some urea adsorbent. Three hours of application of the artificial kidney system with regenerative dialysate to experimental uremic dogs resulted in an improvement of their uremic symtoms.